Measurement of plasma concentrations of yokukansan in form of suppository to healthy Japanese volunteers

Measurement of plasma concentrations of yokukansan in form of suppository to healthy Japanese volunteers - Pharmacokinetics of yokukansan component in form of suppository to healthy Japanese volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012965

Enrollment

Registered

2014-01-26

Start date

2014-01-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy Japanese volunteers

Interventions

Blood sampling time: before, and 0.5, 1, 2, and 4 hour after the enteric administration with 7.5g yokukansan Blood sampling time: before, and 0.5, 1, 2, and 4 hour after the oral administration with

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: a) Healthy volunteers b) Agreement to sign an informed consent

Exclusion criteria

Exclusion criteria: a) Patients who are allergic to medicines, or foods related to the test material of this trial b) Pregnant women, lactating women, or women who want to get pregnant during the trial period c) Patients who are enrolled in the other clinical trials before the agreement for the participation to this trial d) Patients who are judged not suitable to participate in this trial by physician.

Design outcomes

Primary

Measure	Time frame
Time course of plasma levels of hirsuteine and geissoschizine methylether after enteric administration of yokukansan	—

Secondary

Measure	Time frame
Time course of plasma levels of hirsuteine and geissoschizine methylether after oral administration of yokukansan	—

Countries

Japan

Contacts

Public ContactRyoko Kawahara

Nissay Hospital Anesthesiology and Palliative care

kawahara.ryoko@nissay-hp.or.jp06-6543-3581

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026