Effects of aprepitant on cognitive functions in heavy drinkers using fMRI

Effects of aprepitant on cognitive functions in heavy drinkers using fMRI - Effects of aprepitant on cognitive functions in heavy drinkers using fMRI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012945

Enrollment

Registered

2014-02-24

Start date

2014-02-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Control subjects 1day 1 time aprepitant 125 mg Washout duration 1 week 1day 1 time placebo Control subjects 1day 1 time placebo Washout duration 1 week 1day 1 time aprepitant 125 mg Heavy dr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects with no history of psychiatric disorders. Subjects who have the ability to provide informed consent and adhere to the protocol. In heavy drinkers, subjects who consume an average of 60g/day or more of alcohol.

Exclusion criteria

Exclusion criteria: Subjects taking drugs within 1 week of the trial. Subjects with liver, renal, and heart diseases. Subjects with contraindications to MRI. Subjects who are judged as not suitable for participation in this study.

Design outcomes

Primary

Measure	Time frame
Comparison of BOLD signal changes measured by fMRI between placebo and apreppitant conditions in control subjects and heavy drinkers.	—

Countries

Japan

Contacts

Public ContactYumiko Ikeda

Nippon Medical School Department of Pharmacology

y-ikeda@nms.ac.jp03-3822-2131

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026