Investigation of incretin's effect using clamp method

Investigation of incretin's effect using clamp method - Kobe Insulin Clearance Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012914

Enrollment

Registered

2014-01-21

Start date

2014-01-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

hyperglycemic clamp without pre-treatment hyperglycemic clamp after 30 min Lixisenatide 20 micro g SI hyperglycemic clamp after sitagliptin 50 mg PO for 7days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult NGT

Exclusion criteria

Exclusion criteria: 1) drug allergy for Lixisenatide or Sitagliptin 2) Liver or renal impairment 3) Pregmant or breast feeding

Design outcomes

Primary

Measure	Time frame
the ratio of the area under the curve of IRI / CPR under first phase of hyperglycemic clamp	—

Countries

Japan

Contacts

Public ContactKazuhiko Sakaguchi

Kobe University School of Medicine Diabetes and Endocrinology

kzhkskgc@med.kobe-u.ac.jp078-382-5861

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Investigation of incretin&#39;s effect using clamp method