Healthy volunteers
Conditions
Interventions
Sample and dose: L-citrulline 5600mg/day period: 8 days
Sample and dose: L-citrulline 800mg/day and cellulose 4800mg/day period: 8 days
Sample and dose: cellulose 5600mg/day (placebo) period: 8
Sponsors
C'est la vie Shinbashi Clinic, Medical Corporation Shinkokai
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy and right-handed subjects. In female subjects, menopose occurred more than 6 months ago.
Exclusion criteria
Exclusion criteria: 1) regular medication for circulation system and central nerves system 2) history of psychiatric disorders or cerebrovascular diseases 3) serious liver, kidney, heart, respiratory, endocrine, or metabolic diseases 4) marked abnormal findings for blood and urine tests 5) smoker 6) heavy drinker of alcohol 7) obesity (BMI >= 30)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) The changes in the oxy-Hb concentration and amplitudes and latencies of P300 of event-related potentials 2) Performance of the tasks 3) Psychological tests by using the visual analog scale (VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) vital signs (blood pressure and heart rate) 2) blood test (white blood cell count, red blood cell count, hemoglobin, hematocrit, and platelet count) 3) serum chemistry test (serum total protein, albumin, AST, ALT, LDH, gamma-GTP, urea nitrogen (UN), creatinine, uric acid (UA), sodium, chloride, potassium, total cholesterol, LDL cholesterol, HDL cholesterol, and blood glucose) 4) urinalysis (occult blood, urinary protein, urinary glucose, and urobilinogen) | — |
Countries
Japan
Contacts
Public ContactYoshihiko Koga
Kyorin University School of Medicine Department of Neuropsychiatry
Outcome results
None listed