Evaluation of myocardial sympathetic activity and myocardial blood flow assessed by the C-11 hydroxyephedrine and O-15 water PET/CT in patients who underwent implantable cardioverter-defibrillator for the treatment of ventricular arrhythmia.

Evaluation of myocardial sympathetic activity and myocardial blood flow assessed by the C-11 hydroxyephedrine and O-15 water PET/CT in patients who underwent implantable cardioverter-defibrillator for the treatment of ventricular arrhythmia. - Evaluation of myocardial sympathetic activity and blood flow for the patients with ventricular arrhythmia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012824

Enrollment

Registered

2014-01-11

Start date

2013-01-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventricular arrhythmia

Interventions

C11-hydroxyephedrine 185MBq, intravenous infusion at PET/CT scan O15-water 500MBq, intravenous infusion at PET/CT scan

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We will include patients with ventricular arrhythmia who regularly come to Department of Cardiology at Hokkaido University Hospital, and who satisfy all criteria as shown below. 1) Patients who is more than 20 years old at registration. 2) Patients with severe ventricular arrhythmia who need either ICD or CRTD according to the guideline of Japanese Circulation Society. 3) Patients who consented this study under enough understanding after sufficient explanation from us.

Exclusion criteria

Exclusion criteria: We will exclude the patients who satisfy any criteria as shown below. 1) Patients do not agree with the study protocol. 2) Patients who are expected to die within a year. 3) Patients who will be scheduled cardiac surgery or who underwent cardiac surgery within 3 months. 4) Patients who are expected to be difficult to follow up. 5) Patients whom we judge as inappropriate for this study.

Design outcomes

Primary

Measure	Time frame
The changes of myocardial sympathetic activity in patients with ventricular arrhythmia after ICD implantation.	—

Secondary

Measure	Time frame
The effect for ICD discharge or sudden cardiac death by changes of regional myocardial sympathetic activity.	—

Countries

Japan

Contacts

Public ContactNaya Masanao

Hokkaido University Hospital Department of Cardiology

naya@med.hokudai.ac.jp011-716-1161

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026