Stage IVb endometrial cancer
Conditions
Interventions
Sponsors
Japanese Gynecologic Oncology Group
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Cases with tumor in the endometrium by diagnostic imaging such as CT or MRI and cases with a diagnosis of confirmed endometrial carcinoma such as endometrioid adenocarcinoma, serous adenocarcinoma, clear cell adenocarcinoma or adenosquamous carcinoma by histopathologic examination of endometrium 2) Cases with distant metastasis out of the cavity of lesser pelvis or lymph node metastasis except for regional lymph node and cases with FIGO Stages IVb 3) Patients with no previous treatment such as surgery, chemotherapy or radiation therapy for endometrial cancer 4) Performance status (PS):0-2 5) More than 20 years old and less than 75 years old 6) Adequate bone marrow, cardiac, hepatic and renal functions 7) Patient must have signed informed consent
Exclusion criteria
Exclusion criteria: 1) Cases with a possibility of Primary cancer in other organs such as Cervical cancer or Ovarian cancer by diagnostic imaging 2) Patients with symptoms of brain metastases and bone marrow metastasis 3) Patients with active infection 4) Serious complications (heart disease, uncontrolled diabetes mellitus, malignant hypertension and tendency to bleeding) 5) Patients who have a synchronous malignancy or who have been progression-free less than 5 years for a metachronous malignancy 6) Patients with any signs of interstitial pneumonia or pulmonary fibrosis by chest radiography and CT 7) Massive pleural effusion or ascites 8) Neuropathy grade 3 or more (NCI-CTC) 9) Edema grade 3 or more (NCI-CTC) 10) Patients who have had a hypersensitivity reaction to polyoxyethylated or hydrogenated castor oil 11) Patients judged inappropriate for this study by the physicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| surgical operation ratio | — |
Countries
Japan
Contacts
Public ContactToru Nakanishi, M.D.
JGOG2046 Coordinating Office Tohoku Medical and Pharmaceutical University Hospital
Outcome results
None listed