Caridiovascular reflex responses to temporal reduction in arterial pressure during and after intravenous sedation

Caridiovascular reflex responses to temporal reduction in arterial pressure during and after intravenous sedation - Intravenous sedation and circulatory regualation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012787

Enrollment

Registered

2014-01-08

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy male volunteers

Interventions

Midazolam is administered at an initial bolus dose of 0.5 mg, and the additional bolus dose of 0.5 mg is administrated every 2 min after OAA/S assessment until OAA/S 3 (responds only after name is cal

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy male consented to participate in this study.

Exclusion criteria

Exclusion criteria: 1) Not satisfy selection criteria noted above. 2) Volunteers having allergic factors to foods and/or drugs.

Design outcomes

Primary

Measure	Time frame
Arterial blood pressure, heart rate, stroe volume, autonomic circulatory regulation, and sedation depth.	—

Secondary

Measure	Time frame
cerebral circulation, and respiratory condition.	—

Countries

Japan

Contacts

Public ContactYojiro Ogawa

Nihon University School of Medicine Division of Hygiene, Department of Social Medicine

ogawa.yojiro@nihon-u.ac.jp03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026