The effects of midazolam and flumazenil on cerebral circulation

The effects of midazolam and flumazenil on cerebral circulation - Midazolam, flumazenil and cerebral circulation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012777

Enrollment

Registered

2014-01-07

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy subjects

Interventions

Healthy male subjects receives midazolam followed by flumazenil. Midazolam is administered at an initial bolus dose of 0.5 mg, and an additional bolus dose of 0.5 mg is administered every 2 min after

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy male consented to participate in this study.

Exclusion criteria

Exclusion criteria: 1) Not satisfy selection criteria noted above. 2) Volunteers having allergic factors to foods and/or drugs.

Design outcomes

Primary

Measure	Time frame
Cerebral blood flow velocity, arterial blood pressure, sedation depth, and cerebral circulation.	—

Secondary

Measure	Time frame
Heart rate, respiratory condition, and autonomic circulatory regulation.	—

Countries

Japan

Contacts

Public ContactYojiro Ogawa

Nihon University School of Medicine Division of Hygiene, Department of Social Medicine

ogawa.yojiro@nihon-u.ac.jp03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026