Hypertension
Conditions
Interventions
To switch the previous ARB(Losartan, Candesartan, Valsartan, Telmisartan, Olmesartan) to Irbesartan, then treat the patients for 24 weeks.
To continue the previous ARBs (Losartan, Candesartan, Valsa
Sponsors
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Medicine and Clinical Sciences,
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The uncontrolled out-patients with hypertension who have treated with the other ARBs (Losartan, Candesartan, Valsartan, Telmisartan, Olmesartan) for more than 3 months.
Exclusion criteria
Exclusion criteria: The patients with 1) severe renal dysfunction (Cr > 2.0 mg/dl) 2) severe hepatic dysfunction (AST or ALT > 100IU/l) 3) the history of severe side effect of ARBs 4) pregnancy or lactation 5) malignancy or other poor-prognosis disease 6) those who are considered inappropriate by physician
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Change in the clinic and home blood pressure, renal function(serum creatinine, uric acid, pottasium, eGFR), Lipids(LDL-C, HDL-C, T.cho), U-Alb/Cr | — |
Primary
| Measure | Time frame |
|---|---|
| Change in MCP-1, MDA-LDL, Pentraxin-3, hs-CRP | — |
Countries
Japan
Contacts
Public ContactHaruhito Adam Uchida
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Medicine and Clinical Sciences,
Outcome results
None listed