Effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery

Effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery - Effects of a novel method of anesthesia combining propofol and volatile anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012744

Enrollment

130

Registered

2014-01-01

Start date

2009-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients scheduled for elective laparoscopic gynecological surgery

Interventions

In the sevoflurane/propofol group, anesthesia is maintained with combined propofol and sevoflurane. In the sevoflurane group, anesthesia is maintained with sevoflurane. In the propofol group, anesthes

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients scheduled for elective laparoscopic gynecological surgery under general endotracheal anesthesia, with an American Society of Anesthesiologists (ASA) physical status of I and II.

Exclusion criteria

Exclusion criteria: Obesity (body mass index > 33 kg/m2) Neurological, renal, or liver disease Use of drugs with antiemetic properties,including corticosteroids

Design outcomes

Primary

Measure	Time frame
Complete response (no postoperative nausea and vomiting and no rescue antiemetic use) rate within 24 h of surgery	—

Secondary

Measure	Time frame
Incidence of nausea and vomiting Nausea severity score Vomiting frequency Rescue antiemetic use Postoperative pain	—

Countries

Japan

Contacts

Public ContactHiroaki Kawano

Tokushima Prefectural Central Hospital Department of Anesthesiology

hir.kawano@gmail.com088-633-7151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026