Effects of sitagliptin on daily glucose fluctuation in Japanese type 2 diabetic outpatients inadequately controlled with insulin therapy

Effects of sitagliptin on daily glucose fluctuation in Japanese type 2 diabetic outpatients inadequately controlled with insulin therapy - Effects of sitagliptin on daily glucose fluctuation in Japanese type 2 diabetic outpatients inadequately controlled with insulin therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000012735

Enrollment

Registered

2013-12-31

Start date

2012-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)HbA1c value is between 6.5% and 8.4%. 2)Type 2 diabetic outpatients medicated with insulin therapy for more than 6 months.

Exclusion criteria

Exclusion criteria: 1)Type 1 diabetic patients. 2)Patients with severe renal failure. 3)Patients medicated with DPP-4 inhibitor or GLP-1 receptor agonist before start of this study. 4)Patients who are pregnant or in lactation period. 5)Juged as ineligible by clinical investigators.

Design outcomes

Primary

Measure	Time frame
the change of daily glucose fluctuation (MAGE, SD) and oxidative stress (8-iso PGF2)	—

Secondary

Measure	Time frame
the change of HbA1c, fasting plasma glucose level, 1,5-AG, hs-CRP, incidence of hypoglycemia and feeling of distress.	—

Countries

Japan

Contacts

Public ContactYoshiro Kato

Aichi Medical University Division of Diabetes, Department of Internal Medicine, Diabetes Center

ykato4@aichi-med-u.ac.jp0561-63-1683

Outcome results