Comparative study of bone formation and remodeling between Hydroxyapatite/collagen composite and Beta TCP filled in the opening wedge after OWHTO-prospective randomized study-

Comparative study of bone formation and remodeling between Hydroxyapatite/collagen composite and Beta TCP filled in the opening wedge after OWHTO-prospective randomized study- - Comparative study of bone formation and remodeling between Hydroxyapatite/collagen composite and Beta TCP after OWHTO-prospective randomized study-

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012711

Enrollment

Registered

2014-01-01

Start date

2013-12-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis of the knee joint, osteonecrosis of the knee joint

Interventions

Hydroxyapatite/collagen composite (ReFit, Hoya corp.Tokyo, Japan) group beta-TCP (OSferion, Olympus Terumo Biomaterial Corp. Tokyo, Japan) group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients who agree for participation in this study , were undergone opening wedge HTO, and also were able to followed-up more than a year after the operation.

Exclusion criteria

Exclusion criteria: The patients whose postoperative course was significantly different from the ordinary course because of the other reasons of the side effects including breakage of fixation device.

Design outcomes

Primary

Measure	Time frame
Evaluations of bone formation and remodeling using serial radiographs, and clinical outcome measures including JOA (Japanese Orthopedic Association) score for osteoarthritis of the knee joint and JKOM (Japanese Knee Osteoarthritis Measure)	—

Countries

Japan

Contacts

Public ContactAtsuto Hoshikawa

Saitama Medical Centre, Saitama Medical University Department of Orthopaedic Surgery

hiraoka@saitama-med.ac.jp+81-49-228-3627

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026