Type B Acute Aortic Dissection
Conditions
Interventions
60bpm using beta-blocker
Heart rate control to 60-80bpm using beta-blocker
Sponsors
Saiseikai Kumamoto Hospital Intensive Care Unit
Saiseikai Matsuyama Hospital Saiseikai futsukaichi Hospital Saiseikai Oomuta Hospital Saiseikai Yokohamashi Tobu Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)The admitted patient with type B acute aortic dissection within two days after the onset 2)The patient that the agreement by the sentence is provided having ability for agreement
Exclusion criteria
Exclusion criteria: 1) Cardiac tamponade, Organ ischemia, >50mm in maximum aortic diameter 2) Contraindications of beta-blocker including bronchial asthma 3) Marfan syndrome 4) Shock vital including <100mmHg in systolic blood pressure 5) The less than one year in survival prognosis due to malignancy et al 6) The participation in this study is not appropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate and Aortic event : aortic rupture, The progression of aneurysm (>5mm / 6 months), The requirement of surgical intervention including stent-grafting. These events will be determined to be based on the CT findings at admission, 1week and 2weeks after the admission, 1month, 3months, 6months, 1year, 1.5years, 2years after the discharge, and the occurence of aortic symptom. | — |
Secondary
| Measure | Time frame |
|---|---|
| The expansion rate of aortic diameter, The length of intensive care unit stay, The length of hospital stay, The agitation and delirium (scaling score), Hypoxia, (PaO2/FiO2 ratio), Acute kidney injury, The length of the required intra-venous anti-hypertensive medicine,sedative score. Blood chemical examination: the count of white blood cell, red blood cell, and platelet, hemoglobin, hematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen, fibrinogen degradation products, plasmin-alpha2 plasmin inhibitor complex, thrombin- antithrombin complex, D-dimer, antithrombin three, total protein, albumin, total bilirubin, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, lactate dehydrogenase, alkaline phosphatase, creatine phosphokinase, uric acid, blood urea nitrogen, creatinine, serum sodium, serum potassium, serum chloride, C-reactive protein, brain natriuretic peptide, catecholamine 3 fractionation, plasma renin activity, transforming growth factor-beta. | — |
Countries
Japan
Contacts
Public ContactTakashi Unoki
Saiseikai Kumamoto Hospital Intensive Care Unit
Outcome results
None listed