acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress syndrome
Conditions
Interventions
Thrombomodulin
Sponsors
Chiba University
ShinonoiGeneral Hospital First Department of Internal Medicine, Shinshu University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The diagnosis of AE-IPF was based on the criteria, which state that all of the following three conditions must be satisfied during the course of IPF with an unexplained worsening of dyspnea within one month: (1) increased dyspnea, (2) new HRCT appearance, (3) greater than 10-mmHg decreases in oxygen partial pressure (PaO2) in the resting arterial blood compared to previous measurements. The typical HRCT appearance of AE-IPF involved ground glass opacity and/or consolidation as a new appearance on honeycombing. The criteria for the diagnosis of ARDS, as set by the Berlin Definition
Exclusion criteria
Exclusion criteria: The AE-IPF-patients were excluded if they had obvious signs of infection, preexisting pulmonary embolisms, left heart failure, pulmonary hypertension due to pulmonary thromboemboli or phlebitis based on the findings of color Doppler ultrasonography or enhanced HRCT. Patient or family refusal for invasive mechanical ventilation was an exclusionary criterion for endotracheal intubation. Such patients were excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The outcomes of patients included the 28-day mortality and in-hospital mortality after beginning treatment with rhTM were compared with those of untreated patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| We investigated whether or not they showed any improvement in oxygenation (SpO2/FIO2) and intravascular coagulation disturbance (TAT, FDP) in the acute phase. | — |
Countries
Japan
Contacts
Public ContactKenji Tsushima
Chiba University Department of Respirology, Graduate School of Medicine
Outcome results
None listed