A double-blind, placebo controlled, randomized trial to evaluate the efficacy of Abound (nutrition product including HMB, arginine, and glutamine) on the incidence of wound complications in patients with open surgery.

A double-blind, placebo controlled, randomized trial to evaluate the efficacy of Abound (nutrition product including HMB, arginine, and glutamine) on the incidence of wound complications in patients with open surgery. - A double-blind, placebo controlled, randomized trial of Abound in patients with open surgery.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012553

Enrollment

Registered

2013-12-12

Start date

2013-12-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal malignant tumor

Interventions

A: Abound B: placebo (orange juice)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Planning open surgery for gastrointestinal stromal tumors. 2) Aged 20 or older. 3) Adequate organ function. 4) Judgement as being able to take orally preoperatively. 5) An ECOG performance status of 0 or 1. 6) Written informed consent.

Exclusion criteria

Exclusion criteria: 1) Previous abdominal operative scar. 2) Emergency surgery. 3) Uncontrollable diabetes millutus or administration of insulin. 4) Systemic steroids medication. 5) Active bacterial or fungous infection. 6) Other conditions judged as inappropriate for the study by the investigator.

Design outcomes

Primary

Measure	Time frame
The incidence of wound complications	—

Secondary

Measure	Time frame
The incidence of postoperative complications except wound complications, Postoperative hospital stay, muscle mass (skeletal muscle mass, grip strength), moisture content of the skin.	—

Countries

Japan

Contacts

Public ContactYukinori Kurokawa

Osaka University Graduate School of Medicine Department of astroenterological Surgery

ykurokawa@gesurg.med.osaka-u.ac.jp06-6879-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026