Inclusion Criteria Patient with 24 hours or more after surgical intervention. Over 4 points by Disseminated intravascular coagulation diagnostic criteria established by the Japanese Association for Acute Medicine Antithrombin activity below 50%. Sepsis criteria of SCCM/ACCP
Conditions
Interventions
once daily intravenous infusion of 3000 unit of antithrombin concentrate
intravenous infusion of 380 unit/kg of recombinant human soluble thrombomodulin after infusion of 1500 unit of antithrombin
Sponsors
EASTAR workshop
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria Patient with 24 hours or more after surgical intervention. Over 4 points by Disseminated intravascular coagulation diagnostic criteria established by the Japanese Association for Acute Medicine Antithrombin activity below 50%. Sepsis criteria of SCCM/ACCP
Exclusion criteria
Exclusion criteria: 1.Under 20 years old 2.Patient who cannot obtained its consent 3.Patients who are inadequate to enter this study due to other reasons by physician's judgments. 1.Leukemia 2.Patient treated with radiation/anticancer drug 3.Cirrhosis with Child-Pugh grade C or over 4.Patient with hemorrhagic disease (e.g. peptic ulcer after cerebral hemorrhage) 5.Patients with return of cardiopulmonary arrest 6.Patients who cannot survive after 28days judged by physician 7.Patients with past history of hypersensitivity to ATIII concentrate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of coagulation markers at day4. | — |
Countries
Japan
Contacts
Public ContactYutaka Eguchi
Shiga university of medical science Department of Emergency and Intensive care
Outcome results
None listed