Effect of high-dose angiotensin II receptor blocker (ARB) monotherapy versus combination therapy of ARB with calcium channel blocker on vascular endothelial function in patients with essential hypertenson

Effect of high-dose angiotensin II receptor blocker (ARB) monotherapy versus combination therapy of ARB with calcium channel blocker on vascular endothelial function in patients with essential hypertenson - Effect of high-dose ARB monotherapy versus combination therapy of ARB with CCB on vascular endothelial function in patients with essential hypertenson

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012538

Enrollment

Registered

2013-12-10

Start date

2010-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

essential hypertension

Interventions

valsartan 160mg/day valsartan 160mg/day+amlodipine 5mg/day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients not achieve the target blood pressure

Exclusion criteria

Exclusion criteria: 1. History of ischemic heart disease 2. History of cerebrovascular disease 3. patients with renal dysfunction(serum creatinine greater than 1.5mg/dL) 4. patients with diabetes who are poor blood sugar control(HbA1c greater than8.0%) 5. By the change of antihypertensive drugs, blood pressure instability is suspected. 6. patients who takes high-dose ARB

Design outcomes

Primary

Measure	Time frame
vascular endothelial function	—

Countries

Japan

Contacts

Public ContactKoichi Sohmiya

Osaka Medical College Internal Medicine3

in3025@poh.osaka-med.ac.jp072-683-1221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026