Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation

Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation - Clinical application of corneal endothelial regenerative medicine by means of cultured human corneal endothelial cell transplantation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012534

Enrollment

Registered

2013-12-09

Start date

2013-12-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bullous Keratopathy

Interventions

ROCK inhibitor caltivated human corneal endothelial cell

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: BSCVA under 0.5 Corneal thickness over 630 micro meter with corneal epithelial edema corneal endothelial cell density unmesurable or under 500cells per mm2

Exclusion criteria

Exclusion criteria: corneal infection pregnant bleeding tendency mental disability uncontrolable glaucoma uncontrolable diabetes autoimmune disease cancer patient heart disease

Design outcomes

Primary

Measure	Time frame
Corneal Endothelial Cell Density > 500 cells/mm2 (24W)	—

Secondary

Measure	Time frame
Corneal Thickness < 630 micro meter and no corneal epithelial edema Improvement of visual acuity (24W) Improvement of VFQ-25 (24W)	—

Countries

Japan

Contacts

Public ContactMorio Ueno

Kyoto Prefectural University of Medicine Ophthalmology

mueno@koto.kpu-m.ac.jp075-251-5578

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026