pancreatic cancer
Conditions
Interventions
Induction chemotherapy with GEM/n-P followed by GEM/n-P CRT.
Sponsors
Department of Gastroenterological Surgery, Osaka Medical Center for Cancer & Cardiovascular Diseases
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Patients with BR pancreatic cancer involving 180 degree of less of the circumference of the SMA, CA, or CHA. (2)Performance Status (ECOG): 0 or 1 (3)Adequate bone marrow reserves, liver/renal functions: WBC: >=3500/mm3, =<;12000/mm3 Neutrophil: >=1500/mm3 Platelet: >=100000/mm3 Hb: >=9.5g/dL AST, ALT, AL-P: less than twofold of the upper limit of normal range T-Bil: =<1.5mg/dL Cr: =<1.2mg/dL CCr: >=50ml/min PaO2: >=70torr (4)Life expectancy more than 6 months (5)Written informed consent
Exclusion criteria
Exclusion criteria: (1)evident infection (2)Lung fibrosis or intestinal pneumonia, and anamnesis or imaging findings. (3)Severe complication(liver cirrhosis, uncontrolled diabetes etc) (4)the onset of myocardial infarction within 3 months (5)active synchronous malignancy (6) Pregnant or lactation women, or women with known or suspected pregnancy and men who want let to pregnancy (7)history of severe drug allergy (8)neuropathy (9)patients who are judged inappropriate for the entry of the trial by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety | — |
Countries
Japan
Contacts
Public ContactHidenori Takahashi
Osaka Medical Center for Cancer and Cardiovascular Diseases Gastroenterological Surgery
Outcome results
None listed