heart failure
Conditions
Interventions
treatment with oral topvaptan
treatment with carperitide and fulosemide injection
Sponsors
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) NYHA class II or III heart failure patient with volume overload 2) patient who can take medicine orally 3) patient who's systolic blood pressure is 90 mmHg or more at hospital admission 4) patient who is at least 20 years old when he or she agreed to this study 5) patient who agreed within 24 hours after hospital admission
Exclusion criteria
Exclusion criteria: 1) heart failure patient by coronary artery disease 2) patient who has allergic past history to tolvaptan or relative chemicals 3) patient of no urine production 4) patient who do not feel thirsty or have difficulty to take water orally 5) patient who is hypernatremia 6) patient who is pregnant or might be pregnant 7) patient who is very low blood pressure or cardiogenic shock state 8) patient who suffers right ventricular myocardial infarction 9) patient who have dehydration 10) patient who is assessed to be inappropriate for the study by study investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average urinary volume in a day and body weight change, at fifth or the last day of the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) NT-proBNP; before and fifth or the last day of the treatment 2) serum Na, K, creatinie; before and fifth or the last day of the treatment 3) IVC diameter by echocardiography; before and fifth or the last day of the treatment 4) urinary osmorarity; before and fifth or the last day of the treatment 5) oxidative stress marker change; serum and urine 6) event frequency during 90 days after hospital discharge 7) cost of heart failure treatment during hospital admission; cost of treatment or admission fee | — |
Countries
Japan
Contacts
Public ContactYuji Koide
Nagasaki University Hosital Cardiovascular Medicien
Outcome results
None listed