Aortic stenosis
Conditions
Interventions
Pravastatin group
Standard group
Sponsors
St Luke's International Hospital Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients to who TAVI is scheduled. Patient who has severe AS and symptomatic. AVA is 18-28mm. Distance between annulus-coronary artery>10mm. Creatinine level<2.0mg/dl, Expected life expenctency >1y, Indication for TAVI is decided by heart team. 2) Normal LDL and high LDL patients LDL level must be higher than 50mg/dl in 2 measurements. If less than 50mg/dl, 3rd measurement is allowed. Average LDL level must be higher than 50mg/dl.
Exclusion criteria
Exclusion criteria: 1) Familial hypercholesteremia 2) Previous TAVI 3) Congenital heart disease 4)Severe liver dysfunction or renal dysfunction 5) Nephrotic syndrome 6) Hypothyroidism 7) Cusing syndrome 8) Steroid therapy 9) Past history of allergic reaction for statins 10) pregnant female 11) Unconsented by patients or therapist 12) Patients who has been treated with statins for coronary artery diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MI Cardiac/non cardiac death stroke Unplanned pacemaker implantation unplanned open chestsurgery Unplanned peripheral vascular intervention/surgical repair Life thretening bleeding Unplanned admossion due to valve failure Acute renal injury with 3-fold increment of serum cretinine level | — |
Secondary
| Measure | Time frame |
|---|---|
| Pressure Gradient Aortic valve Area | — |
Countries
Japan
Contacts
Public ContactHirotsugu Mitsuhashi
St Luke's International Hospital Cardiovascular Center
Outcome results
None listed