Angina pectoris
Conditions
Interventions
Ultrasonic irradiation (Ultrasonic irradiation to the heart for 20 minutes x 3 times).
Placebo therapy.
Sponsors
Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Informed consent in writing. 2) Men and women 20 years of age or older. 3) Patients who are able to be admitted to a hospital for at least 6 days. 4) Patients with refractory angina pectoris who have no indication of revascularization (PCI or CABG) or in whom the risk of revascularization therapy does not meet the expected improvement. 5) Patients who have chest pain even under standard medical therapy and use at least one use of nitrates per week. 6) Evidence of myocardial ischemia with myocardial stress-scintigraphy. 7) Able to fill out a trial notebook for recording the frequency of nitrate use and chest pain.
Exclusion criteria
Exclusion criteria: 1) Patients whose target area cannot be observed with echocardiography. 2) Intracardiac thrombus. 6) Less than 28 days after the last revascularization (PCI or CABG). 4) Q-wave myocardial infarction within 28 days. 5) Non-Q-wave myocardial infarction within 42 days. 6) Cardiogenic shock or worsening heart failure (to require continuous infusion of cardiovascular agents such as inotropic agents or vasodilator ). 7) Patients whose clinical condition changed after the last coronary angiography. 8) Uncontrolled diabetic retinopathy. 9) Patients who have malignant tumor or who have undergone surgery because of malignancy within the past five years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency in use of nitrates per week. | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom (CCS class scores, Frequency of chest pain per week). Exercise tolerance (Treadmill test, 6-minute walk test). Myocardial perfusion (Stress myocardial perfusion scintigraphy). Cardiac function (only in pts. with LVEF =< 40%). | — |
Countries
Japan
Contacts
Public ContactTomohiko Shindo
Tohoku University Department of Cardiovascular Medicine
Outcome results
None listed