Treatment of the genetic defect of cholesterol biosynthetic pathway by the topical application of statin and cholesterol

Treatment of the genetic defect of cholesterol biosynthetic pathway by the topical application of statin and cholesterol - Treatment of the genetic defect of cholesterol biosynthetic pathway

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012355

Enrollment

148

Registered

2013-11-19

Start date

2013-11-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CHILD syndrome Conradi-Hunermann-Happle syndrome Atopic dermatitis Psoriasis vulgaris Seborrheic dermatitis Porokeratosis

Interventions

Topical application of 1% atorvastatin/ 2% cholesterol Topical application of oxiconazole cream

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients of CHILD syndrome or Conradi syndrome confirmed by genetic diagnosis Patients of atopic dermatitis, psoriasis vulgaris, seborrheic dermatitis, and porokeratosis diagnosed clinically.

Exclusion criteria

Exclusion criteria: Patients without skin manifestations

Design outcomes

Primary

Measure	Time frame
Improvement of skin erythema and scales	—

Countries

Japan

Contacts

Public ContactAkiharu Kubo

Keio University School of Medicine Department of Dermatology

akiharu@a5.keio.jp03-3353-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026