Assessment of medical treatment of diabetes on comorbid diastolic let-ventricular dysfunction observed by cardiac MRI in diabetic patients

Assessment of medical treatment of diabetes on comorbid diastolic let-ventricular dysfunction observed by cardiac MRI in diabetic patients - DMDHF-CMR

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012209

Enrollment

Registered

2013-11-04

Start date

2013-09-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure with diastolic dysfunction and comorbid diabetes.

Interventions

Oral administration of DPP4 inhibitor sitagliptin for 1 year Oral administration of anti-diabetic drugs except for DPP4 inhibitor sitagliptin for 1 year

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 70y/o or older male and female T2DM diastolic dysfunction positive NYHAI-II No previous Hx of hospitalization due to heart failure No hypertension (SBP less than 150 and DBP less than 90) Approved informed consent

Exclusion criteria

Exclusion criteria: MACE within 3 months LVEF<50% Comorbid atrial fibrillation MR at more than moderate grade Patients taking DPP4i or GLP-1 analog ESRD or HD patient T1DM Malignancy within 5 years Uncontrolled arrhythmia Encontralled hypertension Expecting hospitalization within 6 months Insulin treatment Indication of cardiac surgery liver injury Autoimmune disease Pulmonary fibrosis Unstable AP or coronary spastic angina ASO (>Fontaine grade II) Contraindication for MRI Drug allergy to sitagliptin and any antidiabetic drug.

Design outcomes

Primary

Measure	Time frame
Changes in LV early filling by use of CMR.	—

Secondary

Measure	Time frame
MACE incidence of hospitalization by heart failure Changes in E/e' Changes in NT-proBNP Changes in endothelial function Changes in circulating DPP4 activity and biomarkers	—

Countries

Japan

Contacts

Public ContactYasuko K. Bando

Nagoya University Cardiology

ybando@med.nagoya-u.ac.jp052-744-2147

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026