Type-2 diabetic patients (Type-2 diabetic patients with microalbuminuria or nephropathy)
Conditions
Interventions
Sponsors
Tokyo Jikei University School of Medicine Kashiwa Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Type-2 diabetic patients who meet following criteria: 1)Type-2 diabetes millitus(HbA1c:6.5-8.5%) 2)Urinary albumin creatinin ratio(UACR):30-300mg/gCr 3)Age:30-74(Male and female) 4)Written informed consent are taken for the enrollement
Exclusion criteria
Exclusion criteria: 1)Type-1 diabetes millius 2)Serum creatinin level of more than 1.2mg/dL in male patients and 1.0mg/dL in female patients 3)Diabetic ketosis, diabetic coma or total coma within 6 months 4)Severe infectious disease, before or after surgery, and severe trauma 5)Occurrence of ischemic stroke, hemorrhagic stroke or TIA within 6 months 6)Moderate or severe heart failure (NYHE 3 or 4) 7)Patients who receive other DPP4 inhibitors during 3 month before starting study 8)Under treatment with insulin 9)Pregnant, lactating, possibly pregnant or planning to become pregnant women 10)Past medical history of hypersensitivity to linagliptin 11)Patients considered as inadequate by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)The change of HbA1c at baseline and 24 week after DPP-4 inhibitor treatment. 2)The change of UACR, L-FABP and plasma BNP at baseline and 24 week after DPP-4 inhibitor treatment. 3)The co-relationship between HbA1c reduction and the change of UACR, L-FABP and plasma BNP. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Echocardiography, CAVI 2)Fasting plasma glucose, plasma inflammatory markers 3)Body weight,Blood pressure,plasma lipid 4)Safety | — |
Countries
Japan
Contacts
Public ContactMaya Kano
Tokyo Jikei University School of Medicine Kashiwa Hospital Department of Internal Medicine, Division of Diabetes, Metabolism and Endocrinology
Outcome results
None listed