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Effect of twice daily rabeprazole treatment on sleep disturbances in GERD patients with once daily PPI

Effect of twice daily rabeprazole treatment on sleep disturbances in GERD patients with once daily PPI - Effect of PPI on sleep disturbances in patients with GERD

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000012144
Enrollment
60
Registered
2013-10-28
Start date
2013-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastroesophageal reflux disease

Interventions

Rabeprazole sodium (10mg)

Sponsors

Osaka City University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: A diagnosis of erosive GERD including gradeM was made by the endoscopic examination before the PPI dosage start. The patient who takes a rabeprazole sodium 10mg in the morning after the diagnose of GERD. Patient having less than 95% of % SLEEP by actigraph.

Exclusion criteria

Exclusion criteria: They were pregnant or nursing mother, or used atazanavir sulfate, or had allergy to rabeprazole sodium, Zollinger-Ellison syndrome and peptic ulcer disease. Disease-related exclusion criteria included the following: severe disease of any major body system; malignant disease of any kind; gastrointestinal diseases such as esophageal stricture, primary esophagus motor disorders, systemic sclerosis, severe sleep disorder, depression or any other psychiatric disease associated with worsened QOL, past history of upper gastrointestinal surgery.

Design outcomes

Primary

MeasureTime frame
parameters by actigraph

Countries

Japan

Contacts

Public ContactKeiko Hiramoto

Osaka City University Graduate School of Medicine Osaka City University Graduate School of Medicine

m2039002@med.osaka-cu.ac.jp06-6645-3811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026