Sleep pressure and disordered breathing in resistant hypertension and cardiovascular disease registry

Sleep pressure and disordered breathing in resistant hypertension and cardiovascular disease registry - SPREAD Registry

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000012118

Enrollment

2000

Registered

2013-10-25

Start date

2012-08-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who meet the following criteria: - Refractory hypertension (Patients under treatment with 3 or more antihypertensive agents with office systolic blood pressure of 130 mmHg or higher, or diastolic blood pressure of 80 mmHg or higher) - Cardiovascular disease - Coronary artrey disease: Patients who have a past history of coronary intervention or coronary artery bypass surgery, or diagnosed with coronary disease and receive the medical treatment. - Heart failure: Patients diagnosed with heart failure and receive the medical treatment. - Sleep apnea syndrome (SAS): Apnea hypopnea index (AHI) >5/hr by polysomnography, or suspected SAS and 3% oxygen desaturation index(ODI) 5 and higher, or current medical treatment for SAS. - Peripheral artery disease: Patients diagnosed by imaging and laboratory tests and treated by physician. - Aorta dissection, aortic aneurysm: Patients diagnosed by imaging and laboratory tests and treated by physician. - Atrial fibrillation: Patients diagnosed by imaging and laboratory tests and treated by electrocardiogram.

Exclusion criteria

Exclusion criteria: - Cerebral vascular disease within 6 months (except for asymptomatic or transient ischemic attack) Hemodialysis patients Having other severe diseases (cancer, connective tissue disease) Unwillingness to sign an informed consent. Patient him/herself or his/her family uses medical devices (e.g., pacemaker) which are affected by electric waves from mobile-phone. Patients considered as inappropriate to participate in this study by attending physicians.

Design outcomes

Primary

Measure	Time frame
Total mortality	—

Secondary

Measure	Time frame
Cardiovascular death, Sudden death, Ischemic heart disease, Cerebrovascular disease, De novo arteriosclerosis obliterans, Aortic dissection, heart failure that requires hospitalization, De novo diabetes, De novo atrial fibrillation, and Chronic hemodialysis	—

Countries

Japan

Contacts

Public ContactKazuomi Kario

Jichi Medical University School of Medicine Division of Cardiovascular Medicine, Department of Medicine

spread@jichi.ac.jp0285-58-7344

Outcome results