Combination therapy with diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after laser in situ keratomileusis.

Combination therapy with diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after laser in situ keratomileusis. - Combination therapy with diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after laser in situ keratomileusis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000012111

Enrollment

Registered

2013-10-31

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye

Interventions

Sodium hyaluronate ophthalmic solution Diquafosol sodium ophthalmic solution Combination of sodium hyaluronate ophthalmic solution and diquafosol sodium ophthalmic solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) 20 years old or older. 2) female or male. 3) Patients who will undergo LASIK at Minamiaoyama Eye Clinic.

Exclusion criteria

Exclusion criteria: 1) Patients who need to treat other eye disease. 2) Patients who take some medications causing dry eye. 3) Patients who judged to be not suitable by a doctor.

Design outcomes

Primary

Measure	Time frame
Dry eye symptoms Uncorrected visual acuity Corrected visual acuity Functional visual acuity Manifest refraction	—

Secondary

Measure	Time frame
Tear film breakup time Fluorescein corneal staining Schirmer test Corneal sensitivity	—

Countries

Japan

Contacts

Public ContactIkuko Toda

Minamiaoyama Eye Clinic Ophthalmology

ikuko@tka.att.ne.jp03-5772-1440

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026