Major depressive disorder, Adjustment disorder with depression
Conditions
Interventions
PET
Sponsors
National Institute of Radiological Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age, 20-65 years 2) Normal healthy volunteers or patients with major depressive disorder and adjustment disorder as defined by the criteria of DSM-IV-TR
Exclusion criteria
Exclusion criteria: 1) Subjects who lack the ability to provide informed consent 2) Subjects who take antidepressants except escitalopram, antipsychotics, mood stabilizers, or tandospirone. Subjects who took those medicines in 1 month. 3) Serious suicidal ideation or behavior 4) Co-morbid other psychiatric disorders including drug dependence 5) Existence of brain organic disease, including current or past history of cerebrovascular disease, Parkinson's disease, and other related disorders 6) Existence of serious medical illnesses 7) Pregnant women 8) lactating woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional endogenous serotonin release | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship between regional endogenous serotonin release and density of 5-HT1A receptors, blood analysis, symptom, cognitive function and fMRI. | — |
Countries
Japan
Contacts
Public ContactKazuko Suzuki
National Institute of Radiological Sciences Molecular Imaging Center
Outcome results
None listed