Drug-Resistant Essential Hypertension
Conditions
Interventions
Renal sympathetic denervation with radiofrequency ablation catheter
Sponsors
Kanazawa University Graduate School of Medical Science, Division of Environmental Sience Disease Control and Homeostasis
Department of Cardiovascular Medicine Osaka University graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients whose systolic pressure is beyond 160mmHg in spite of taking more than 3 kinds of antihypertensive drug(patients whose systolic pressure is beyond 150mmHg, if he is a diabetic)
Exclusion criteria
Exclusion criteria: 1)Anatomical anomaly of renal artery inappropriate for the operation 2)Estimated glomerular filtration rate is less than 45mL/min 3)History of myocardial infarction, angina pectoris, or cerebrovascular accident within 6 month 4)Type1 diabetes mellitus 5)Secondary Hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Safety during perioperative period and chronic phase after the operation(evaluated with eGFR and imaging study) 2)Onset or progression of cardiovascular disease | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Safety of the technique in the operation 2)Systolic blood pressure one year after the operation 3)Sympathetic nerve activity after the operartion(evaluated with muscle sympathetic nerve activity and blood hormone such as catecholamine) | — |
Countries
Japan
Contacts
Public ContactHisayoshi Murai
Kanazawa University Graduate School of Medical Science, Division of Environmental Science Disease Control and Homeostasis
Outcome results
None listed