Evaluation of a point-of-care test kit for the detection of periodontal pathogen in the treatment of periodontal disease: a multi-center study

Evaluation of a point-of-care test kit for the detection of periodontal pathogen in the treatment of periodontal disease: a multi-center study - Evaluation of a test kit for the detection of periodontal pathogen

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011943

Enrollment

Registered

2015-09-01

Start date

2013-10-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal disease

Interventions

Following SRP, a microbiological assessment using a test kit is performed. Then, minocycline (Periofeel)is locally delivered to positive sites. Control (Periodontally healthy individuals)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Periodontitis patients with at least one site with PD 4-5 mm (mild periodontitis). 2. Periodontitis patients with at least one site with PD 6-9 mm (severe periodontitis). 3. Periodontally healthy individuals (control) 4. Those who completed full-mouth scaling before the start of the study (baseline). 5. Those who agreed to participate in the study with written informed consent.

Exclusion criteria

Exclusion criteria: 1. Those with uncontrolled systemic diseases (ex. diabetes, hyperlipidemia, cardiovascular diseases, osteoporosis, autoimmune diseases) 2. Smokers 3. Those with aggressive periodontitis 4. History of antimicrobial treatment within 3 months 5. Those who received SRP within 6 months 6. History of allergic reaction against antimicrobials (especially tetracyclines)

Design outcomes

Primary

Measure	Time frame
1. To compare the results from a commercial test(PCR-Invader) and the present test kit in control and periodontitis groups at baseline. 2. To compare the results from a commercial test and the present test kit before and after SRP (scaling and root planing) and after the use of Periofeel.	—

Secondary

Measure	Time frame
The following parameters before SRP, after SRP and after the use of Periofeel. 1)Probing pocket depth 2)Bleeding on probing 3)Clinical attachment level 4)Gingival index 5)Plaque indel 6)Tooth mobility	—

Countries

Japan

Contacts

Public ContactToshiya Morozumi

Niigata University Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences

moro@dent.niigata-u.ac.jp025-227-2869

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026