Granulocyte colony-stimulating factor-mediated neuroprotective therapy for acute aggravation of cervical compressive myelopathy: multicenter placebo controlled randomized single blinded trial.

Granulocyte colony-stimulating factor-mediated neuroprotective therapy for acute aggravation of cervical compressive myelopathy: multicenter placebo controlled randomized single blinded trial. - Granulocyte colony-stimulating factor-mediated neuroprotective therapy for acute aggravation of cervical compressive myelopathy: multicenter placebo controlled randomized single blinded trial.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011938

Enrollment

Registered

2013-10-04

Start date

2013-12-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical compressive myelopathy

Interventions

Granulocyte colony-stimulating factor normal saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Acute aggravation of cervical compressive myelopathy (who showed 2 pts. deterioration of JOA score within 1 month), patients with the voluntary consent documents upon participation, patients who can visit the hospital for one year

Exclusion criteria

Exclusion criteria: allergy for G-CSF, history of the malignancy of hematopoietic system, history of malignancy within 5 years, thoromboembolism, splenomegaly, disturbance of consciousness, pregnancy

Design outcomes

Primary

Measure	Time frame
Attenuation of functional impairment 2 weeks after the drug administration using Japanese Orthopedic Association Cervical Myelopathy Evaluation Score (JOA score).	—

Secondary

Measure	Time frame
Attenuation of motor paralysis (ASIA motor score), attenuation of sensory paralysis (ASIA sensory score), attenuation of quality of life (EQ-5D), spinal cord MRI	—

Countries

Japan

Contacts

Public ContactYukiko Matsumoto

Chiba University Graduate School of Medicine Department of Orthopedics

chibaseikei8f@yahoo.co.jp043-226-2961

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026