essential hypertension
Conditions
Interventions
To start azilsartan at 20 mg (in patients who takes ARB except for azilsartan, to change the ARB to azilsartan 20mg) To increase the dose of azilsartan to 40 mg, if the office BP at week 4 is 140/90
Sponsors
Department of Cardiology, Pulmonology, Hypertension & Nephrology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Outpatients with essential hypertension who take no antihypertensive drugs or standard-dose angiotensin receptor blockers except for azilsartan. 2. Patients with systolic blood pressure 140 mmHg and over or diastolic blood pressure 90 mmHg and over. 3. Patients who were informed of possible risks and benefits from participating in the research, and signed on paper(written informed consent).
Exclusion criteria
Exclusion criteria: 1.Patients with hypersensitivity reaction to azilsartan. 2.Patients with hypersensitivity reaction to dihydropyridine-based compound. 3.Pregnant or nursing mothers. 4.Patients who takes antihypertensive drugs except for angiotensin receptor blockers. 5.Patients with myocardial infarction, heart failure, or stroke within 6 months. 6.Patients withserum creatinine concentration 1.2 mg/dL and over. 7.Patients with elevated liver enzymes (AST or ALT 40 IU/L and over) 8.Patients with systolic blood pressure 180 mmHg and over or diastolic blood pressure 110 mmHg and over.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference of blood pressure lowering effect between azilsartan and amlodipine | — |
Countries
Japan
Contacts
Public ContactTakafumi Okura
Ehime University Graduate School of Medicine Department of Cardiology, Pulmonology, Hypertension & Nephrology
Outcome results
None listed