Healthy adult patients undergoing elective surgery
Conditions
Interventions
Intravenous administration of magnesium sulfate 5mL(2.5mmol) before propofol
Intravenous administration of saline 5mL before propofol
Sponsors
Sapporo Medical University, School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients (American Society of Anesthesiologists physical status I-II) scheduled for elective surgery under general anesthesia without a combination of nerve block.
Exclusion criteria
Exclusion criteria: 1)Daily intake Ca blocker 2)Daily intake antipsychotics 3)Having heart, liver or kidney comprication 4)BMI over 35 5)Having arrhythmia, or AV block 6)Preoperative blood magnesium concentration over 2.6mg/dL 7)Not obtained informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)vascular pain with propofol 2)vascular pain with magnesium 3)time to asleep onset with propofol 4)concentration of propofol at the time of conscious loss | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)frequency of shivering 2)postoperative pain 3)analgesic requirements 4)muscle relaxant requirement during surgery 5)time to onset of muscle relaxant 6)time to awake from anesthesia 7)hemodynamic changes at the induction of general anesthesia | — |
Countries
Japan
Contacts
Public ContactNobuyoshi Matsuoka
Sapporo Medical University, School of Medicine Department of Anesthesiology
Outcome results
None listed