Comparison of effects of a DPP-4 inhibitor and an alpha-glucosidase inhibitor on visceral fat and oxidative stress in type 2 diabetes mellitus

Comparison of effects of a DPP-4 inhibitor and an alpha-glucosidase inhibitor on visceral fat and oxidative stress in type 2 diabetes mellitus - Comparison of effects of a DPP-4 inhibitor and an alpha-glucosidase inhibitor on visceral fat and oxidative stress in type 2 diabetes mellitus

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011864

Enrollment

100

Registered

2013-10-01

Start date

2013-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

treatment with sitagliptin treatment with acarbose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - patients with diabetes mellitus - HbA1c (JDS) of 6.1 to 8.0% - under treatment with 1) diet therapy and exercise, 2) sulphonylurea, 3) metformin, or 4) suophnylurea and metformin

Exclusion criteria

Exclusion criteria: allergy to sitagliptin or acarbose

Design outcomes

Secondary

Measure	Time frame
1) HbA1c 2) high sensitive CRP 3) urinary protein/creatinine ratio, urinary albumin/creatinine ratio, eGFR 4) renin angiotensin system: plasma renin activity, plasma aldosterone concentration, plasma prorenin concentration, plasma soluble (pro) renin receptor, urinary prorenin excretion, urinary (pro)renin excretion 5) body weight, waist circumference, adiponectin 6) endothelial function: flow mediated dilation and nitroglycerin mediated dilation 7) atherosclerosis: CAVI and AI	—

Measure

Time frame

1) HbA1c 2) high sensitive CRP 3) urinary protein/creatinine ratio, urinary albumin/creatinine ratio, eGFR 4) renin angiotensin system: plasma renin activity, plasma aldosterone concentration, plasma prorenin concentration, plasma soluble (pro) renin receptor, urinary prorenin excretion, urinary (pro)renin excretion 5) body weight, waist circumference, adiponectin 6) endothelial function: flow mediated dilation and nitroglycerin mediated dilation 7) atherosclerosis: CAVI and AI

—

Primary

Measure	Time frame
Visceral fat mass and oxidative stress	—

Countries

Japan

Contacts

Public ContactSatoshi Morimoto

Tokyo Women's Medical University Department of Medicine II, Endocrinology and Hypertension

smorimoto@endm.twmu.ac.jp03-3353-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026