A treatment option for refracfory depression
Conditions
Interventions
cTBS (1800): right DLPFC, 1800 pulses/session, 10 sessions/ 2 weeks
iTBS (1800): left DLPFC, 1800 pulses/session, 10 sessions/ 2 weeks
cTBS (1800) + iTBS (1800): cTBS over right DLPFC and iTBS over le
randomized sequences in determining which side to be started with
Sham controlled group: figure-of-eight coil targeted at either side of DLPFC (randomized) with 90 degree against skull
Sponsors
Taipei Veterans General Hospital, Taiwan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Major Depressive Disorder(MDD), no substance abuse and personality disorders (based on DSM-IV) Meet medication-resistant depression: fail to respond to at least 2 trials of adequate antidepressant treatments (dosage and duration) At least moderate depression before TBS: Clinical Global Index of severity >=4 and 17-item Hamilton Depression Rating Scale (HDRS-17)>= 18
Exclusion criteria
Exclusion criteria: No major systemic illness(e.g.,severe arrhythmia);no neurological disorders(e.g., neuro-stimulators, stroke, seizure, traumatic brain injury); Not in pregnant; No brain implants; No pacemakers; No brain surgery past history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maudsley staging scoring questionnaires (baseline); Depressive symptoms: Hamilton Depression Rating Scale-17 (HDRS-17), Depression Subscales for Somatic Symptoms (DSSS), Short-form McHill Pain Questionnaire(MPQ) and Visual Analogue Scores (VAS) Manic symptoms: Young Mania Rating Scales (YMRS) Quality of life: MOS SF-12 quality of life rating scales | — |
Secondary
| Measure | Time frame |
|---|---|
| Nerocognitive testings will be also performed twice, baseline and 2 weeks post-treatment, to check their attention (Test for Attentional Performance) and executive function (Wisconsin Card Sorting Tests). 3T MRI and 18F-FDG PET | — |
Countries
Asia(except Japan)
Contacts
Public ContactCheng-Ta Li
Taipei Veterans General Hospital, Taiwan Psychiatry
Outcome results
None listed