osteoporosis
Conditions
Interventions
Patients included are to be given minodronic acid hydrate
Sponsors
Tottori University, Faculty of Medicine, School of Health Science
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1)Primary osteoporotic patients 2)Patients who take bisphosphonates more than 2 years and do not gain the bone mineral density (lumbar vertebra or hip) over 3 % since prescription of bisphosphonates 3)Age-lower limit: 50 years old, age-higher limit: none 4)Patients able to walk themselves 5)Patients giving informed consent
Exclusion criteria
Exclusion criteria: 1)Secondary osteoporotic patient 2)Patients with peptic ulcers 3)Patients with history of gastrectomy or broad gastrointestinal resection 4)Patients who diagnosed malignancy 4)Patients with obstacles which delays esophagus passage of stricture of the esophagus or achalasia 5) Patients who have raised the upper part of the body for 30 minutes or it cannot be standing 6) Patients with hypersensitivity to bisphosphonates 7)Patients with receiving therapy of SERM or bisphosphonates 8)Patients with receiving therapy of drugs affecting bone metabolism within 8 weeks before study 9)Patients with hypocalcemia 10)Patients with severe hepatic and renal dusfunction and cardiovascular disease 11)Patients with pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1)Newly diagnosed Osteoporotic patients -Changes in bone metabolic markers -Changes in QOL score(SF-8) (2) Other bisphosphonates-treatment resistant osteoporotic patients. -Changes in bone mineral density -Changes in hip structure analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| (1)Newly diagnosed Osteoporotic patients -Correlation between bone metabolic markers -Correlation between the number of incident fracture and the efficacy of MIN -Incidence of new vertebral fracture -Adherence to MIN - Incidence of side effects (2) Other bisphosphonates-treatment resistant osteoporotic patients. -Changes in bone metabolic markers -Correlation between bone metabolic markers and bone mineral density -Correlation between the number of incident fracture and the efficacy of MIN -Incidence of new vertebral fracture -Adherence to MIN - Incidence of side effects | — |
Countries
Japan
Contacts
Public ContactHiroshi Hagino
Tottori University School of Health Science, Faculty of Medicine
Outcome results
None listed