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Radiation-Dose-Lowering Effect of Landiolol Hydrochloride in Coronary Angiography Using Computed Tomography (DELIGHT): A Prospective Multicenter Study

Radiation-Dose-Lowering Effect of Landiolol Hydrochloride in Coronary Angiography Using Computed Tomography (DELIGHT): A Prospective Multicenter Study - Radiation-Dose-Lowering Effect of Landiolol Hydrochloride in Coronary Angiography Using Computed Tomography (DELIGHT): A Prospective Multicenter Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000011817
Enrollment
250
Registered
2013-10-01
Start date
2012-03-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Heart Disease

Interventions

0.125 mg/kg of landiolol hydrochloride was injected for 60 s.

Sponsors

DELIGHT study group
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The patient who has the necessity for the heart rate reduction by beta blocking agent medication with 80 bpm or less heart rate just before administration.

Exclusion criteria

Exclusion criteria: 1)Patients with an implantable cardiac pacemaker or an implantable cardioverter-defibrillator 2)Patients who was previously treated with coronary artery bypass grafting 3)Patients with cardiomyopathy 4)Patients with a valve disease 5)Patients with an advanced bradycardia (heart rate less than 50 bpm) 6)Patients with blood pressure less than 110 mmHg at the time into the CT room 7)Patients with atrial fibrillation or premature beat, and expected them during the CTA 8)Patients with contraindication of landiolol hydrochloride 9)Patients with contraindication of nonionic contrast media 10)Patients with relative contraindication of nonionic contrast media and examination doctor judged to be unsuitable for incorporating 11)Patients who had severe allergy experience 12)Patients under pregnancy and breast-feeding and with the possibility of pregnancy, or the patient who wishes to become pregnant during examination period 13)Patients who examination doctor judged to be unsuitable for incorporating because of another reason

Design outcomes

Primary

MeasureTime frame
We compare exposed dose at CT angiography and the estimated exposure dose by the heart rate just before medication.

Secondary

MeasureTime frame
1) exposed dose at CCTA 2) ratio of the patients who could use prospective gating mode at CT angiograph 3) heart rate, blood pressure 4) assessability of the CCTA 5) adverse events, side effect

Countries

Japan

Contacts

Public ContactTeruhito Kido

Ehime University Graduate School of Medicine Department of Radiology

terukido@m.ehime-u.ac.jp+81-89-960-5371

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026