Subjects who take NSAIDs(including low-dose aspirin) for more than 3 months and are suspected of occult OGIB
Conditions
Interventions
None listed
Sponsors
Department of Gastroenterology, Okayama University Hospital
Iwakuni Medical Center Okayama Saiseikai General Hospital Okayama Citizen'
s Hospital Japanese Red Cross Okayama Hospital Kagawa Prefectual Central Hospital Kurashiki Central Hospital Tsuyama Central Hospital Japanese Red Cross Society Himeji Hospital Fukuyama Medical Center Fukuyama City Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects obtained written informed consent 2) Subjects taking NSAIDs(including commercial drugs and low-dose aspirin) for more than 3 months 3) Subjects who have iron deficient anemia the cause of which is unclear with esophagogastroduodenoscopy and colonoscopy, and are diagnosed Occult OGIB
Exclusion criteria
Exclusion criteria: 1) Pregnant and nursing women 2) Subjects with contraindication of capsule endoscopy(gastrointestinal obstruction, stenosis, or fistula and a disorder of swallowing, etc) 3) Subjects who are judged inappropriate for the participation of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between the number of oxidative stress marker/antioxidant status/regulatory T-cells in serum and the incidence of small intestinal mucosal injury | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) The incidence rate of NSAIDs-induced small intestinal mucosal injury in a capsule endoscopy 2) The correlation between the rate of PPI or H2-RA takers and the extent of small intestinal mucosal injury | — |
Countries
Japan
Contacts
Public ContactYoshiyasu Kono
Okayama University Hospital Department of Gastroenterology
Outcome results
None listed