Mesothelioma
Conditions
Interventions
Patients suspected of having clinical sign of mesothelioma are prospectively enrolled, and these patients will undergo CT-based (plain CT and contrasted CT), MRI-based (T1WI, T2WI, DWI, and contrasted
Sponsors
Saitama Medical University International Medical Center
Japanese Society of Thoracic Radiology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who have recurrence pleural fluid of unknown cause and/or pleural thickening of unknown cause, and indefinite diagnosis of malignant tumor lung cancer or mesothelioma by diagnostic imaging and/or thoracentesis. 2) Both inpatients and outpatients 3) Both men and women 4) Patients aged 20 years or older 5) Patients who had been provided with ample explanation before participating in this clinical study, fully understood the content of the study, and submitted a written consent to voluntarily participate in the study
Exclusion criteria
Exclusion criteria: 1) Patients in whom pathological diagnosis was made 2) Patients who underwent invasive treatment 3) Patients for whom the investigator or subinvestigator(s) judges their participation in the clinical trial to be inappropriate 4) Patients in whom MRI examination is contraindicated (e.g., use of a pacemaker) 5) Patients in whom iodine-based and Gd-based contrast media are contraindicated (e.g., patients with a history of hypersensitivity to these contrast media)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The overall abilities (sensitivity, specificity, and accuracy) to diagnose mesothelioma, disseminated lung cancer, and benign pleural disease (e.g., pleurisy) of various modalities (i.e., contrasted CT, DWI-MRI, and FDG-PET) are compared with those from definite diagnosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| •Characteristic appearances are examined for mesothelioma, disseminated lung cancer, and benign pleural disease (pleurisy). • Diagnostic performance (sensitivity, specificity, and accuracy) is compared among various modalities (i.e., contrasted CT, DWI-MRI, and FDG-PET). | — |
Countries
Japan
Contacts
Public ContactFumikazu Sakai
Saitama Medical University International Medical Center Department of Diagnostic Radiology
Outcome results
None listed