Oral Immunotherapy for Hen's Egg, Cow's Milk, and Wheat allergic children at outpatient clinic. To analyze the safety of causative food ingestion while their interval is gradually wider.

Oral Immunotherapy for Hen's Egg, Cow's Milk, and Wheat allergic children at outpatient clinic. To analyze the safety of causative food ingestion while their interval is gradually wider. - Outpatient Oral Immunotherapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011689

Enrollment

Registered

2013-09-30

Start date

2011-10-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

food allergy

Interventions

The subjects are asked to take a small amount of their causative food at home, and it is built up to target amount gradually depending on their symptoms. The target amount of ingestion, regarding tol

s egg, 200ml of cow&#39

s milk, and 200g of Japanese Udon noodles.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects are confirmed mild or moderate positive objective symptoms caused by hen's egg, cow's milk, or wheat ingestion challenge just before this trial.

Exclusion criteria

Exclusion criteria: The threshold for eliciting positive symptoms is less than one fourth hen's egg, 12ml of cow's milk, or 7g of Udon noodles by oral food challenge test. The subject who is treated by adrenaline injection at oral food challenge test just before this study. The subject who has not-well treated atopic dermatitis, bronchial asthma, or any underlying disease. The subject who is not appropriate for oral immunotherapy, judged by medical doctor.

Design outcomes

Primary

Measure	Time frame
The purpose of this study is to clarify outcome, regarding tolerance acquisition and incidence rate of symptoms by outpatient slow oral immunotherapy.	—

Secondary

Measure	Time frame
To confirm the safety of outpatient oral immunotherapy for mild and moderate food allergic children. The interval of causative food ingestion become gradually wider during the maintenance phase. To clarify the safety of oral immunotherapy with that wide interval method regarding tolerance acquisition.	—

Countries

Japan

Contacts

Public ContactImai Takanori

National Hospital Organization Department of Allergy, Clinical Research Center for Allergy and Rheumatology

foodallergy@sagamihara-hosp.gr.jp042-742-8311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Oral Immunotherapy for Hen&#39;s Egg, Cow&#39;s Milk, and Wheat allergic children at outpatient clinic. To analyze the safety of causative food ingestion while their interval is gradually wider.