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Posterior subtenon injection of triamcinolone acetonide reduces the use of intravitreal bevacizumab for diffuse diabetic macular edema

Posterior subtenon injection of triamcinolone acetonide reduces the use of intravitreal bevacizumab for diffuse diabetic macular edema - Combination therapy for DDME

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000011656
Enrollment
10
Registered
2013-09-05
Start date
2013-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diffuse Diabetic Macular Edema

Interventions

Initially, both eyes of each patient received 1.25mg/0.05ml of intravitreal injection of bevacizumab. One eye then received 20mg/0.5ml of subtenon injection of triamcinolone acetonide at the onset, an

Sponsors

NTT East Japan Tohoku Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Type II diabetic patients whose bilateral DDME with foveal thickness greater than 400 micrometer and with logMAR visual acuity worse than 0.3

Exclusion criteria

Exclusion criteria: Eyes with severe proliferative retinopathy were excluded from the study. Patients with a history of focal or pan retinal photocoagulation and/or cataract surgery in either eye within the 6 months prior to entry into the study, and patients who had previous therapies for DDME, including grid laser treatment, intravitreal injection of any drugs, and/or vitreous surgery, were excluded from this study. Patients with systemic disorders other than hypertension and hypercholesterolemia were excluded from this study.

Design outcomes

Primary

MeasureTime frame
Foveal thickness were monitored monthly for 1-year. The total number of intravitreal injections of bevacizumab injections during the follow-up

Secondary

MeasureTime frame
logMAR visual acuity and intraocular pressure

Countries

Japan

Contacts

Public ContactMasahiko Shimura

Tokyo Medical University Hachioji Medical Center Department of Ophthalmology

masahiko@v101.vaio.ne.jp090-2274-8107

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026