Low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after aortic arch surgery: a randomised controlled trial

Low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after aortic arch surgery: a randomised controlled trial - Kawasaki ANP trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011650

Enrollment

Registered

2013-09-04

Start date

2011-02-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute kidney injury

Interventions

Patients are randomly assigned to receive a fixed dose of atrial natriuretic peptide (0.0125microgram kg-1 min-1) or placebo. The infusion is started after induction of anesthesia and continued for 24

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: a) elective aortic arch surgery; b) preoperative serum creatinine under 1.3 mg/dL

Exclusion criteria

Exclusion criteria: 1) an additional procedure was planned or undertaken 2) the arterial or venous cannulation sites were modified 3) the patient required an ANP infusion to treat perioperative acute heart failure 4) the patient age under 20 years 5) the patient had a history of adverse reaction to atrial natriuretic peptide 6) mean arterial blood pressure could not be maintained above 50 mmHg despite the administration of a positive inotrope or vasopressor after weaning from cardiopulmonary bypass.

Design outcomes

Primary

Measure	Time frame
The primary end point was the incidence of AKI within 48 hours after surgery.	—

Countries

Japan

Contacts

Public ContactYosuke Mori

Kawasaki Saiwai Hospital Department of Anesthesia

yosuke@mori.name044-544-4611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026