Non-cardiac stroke
Conditions
Interventions
Switch Aspirin to Clopidogrel for chronic non-cardiac stroke patients taking Aspirin.
Chronic non-cardiac stroke patients taking Aspirin.
Sponsors
Tokyo Womens Medical University Hospital
Nippon Medical School Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Non-cardiac ischemic stroke patient including asymptomatic ischemic stroke 2) Satisfy the bellow -Taking Aspirin over a month -Definite stroke by CT or MRI -20 years of age or older
Exclusion criteria
Exclusion criteria: Complications 1) Need to manage by oral anti coagulation, e.g., AF or valvular 2) Active gastric ulcer 3) Symptomatic intra cranial bleeding Drugs 1) Anti platelet dugs -Cilostazol, Aspirin, Ticlopidine, Dipyridamole, Salpoglerate, Ozagrel 2) Anti coagulation drugs -Warfarin, Dabigatoran, Rivaroxaban, Apixaben, Heparin, Argatroban 3) NSAIDs Except for using within 7 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of below 1)Any bleedings which should be managed clinically (need to withdraw, reduce the dose and be hospitalized) 2)Using rate of proton pomp inhibitor 3)Rate of continue | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Inflammatory or atherosclerosis marker -hs-CRP, ABI/PWV 2) Side effect -Leukopenia, Neutropenia, Thrombocytopenia, hepatic dysfunction -Gastrointestinal dysfunction 3) Moving of Hb 4) Incidence of ischemic events -Ischemic stroke, TIA -Myocardial infarction -Angina(unstable, stable) -Cardiovascular death 5) Incidence of MBs 6) Echo of carotid artery -maxIMT -echogensity | — |
Countries
Japan
Contacts
Public ContactHiromi Uno
Tokyo Womens Medical University Hospital The Neurological Institute
Outcome results
None listed