Efficacy of high dose metformin treatment in patients with type 2 diabetes mellitus

Efficacy of high dose metformin treatment in patients with type 2 diabetes mellitus - Efficacy of high dose metformin treatment in patients with type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011626

Enrollment

Registered

2013-09-09

Start date

2013-06-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus

Interventions

Group A: Twice-daily taking in first half part Metformin is increased to 1500mg/day. Twice-daily taking are taken continuous over 4 days in first half part and thrice-daily taking are taken continuou

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The patients with type 2 diabetes who are in hospital for glycemic control. 2. Less than 1500mg/day of metformin 3. The patients who have agreed to participate in this study with an informed consent. 4.Age more than 20

Exclusion criteria

Exclusion criteria: 1. Type 1 diabetes 2. Patients contraindicated to metformin 3. Patients judged not to be eligible by the principal investigator

Design outcomes

Primary

Measure	Time frame
Diurnal glycemic profiles	—

Secondary

Measure	Time frame
Continuous Glucose Monitoring Frequency of hyperglycemia Lactate Level	—

Countries

Japan

Contacts

Public ContactYoshihisa Hiromine

Kinki University School of Medicine Department of Endocrinology, Metabolism, and Diabetes

hiromine@med.kindai.ac.jp+81-72-366-0221(ext.3125)

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026