infants high risk for atopic sensitization
Conditions
Interventions
breast feeding (if amounts of breast milk is not sufficient, elemental formula will be added: max 150ml/day) untill starting solid food
breast feeding + formula milk at least 40 ml per day untill star
Sponsors
Jikei University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Be in high-risk group of atopic sensitization: at least one of father, mother, brothers and sisters of infants has atopic diseases (asthma, atopic dermatitis, food allergy, allergic rhinitis, hay fever) 2. Obtained informed consent of written form. a. Participants who understand randomization into two groups: breast feeding with or without amino acid milk and breast feeding with ordinal formula milk. b. Blood examination at 5 - 6 months and 2 years of age are requisite. 3. Be available to visit outpatient clinic for 7 times at 1 month, 3 months, 6 months, 9 months, 1 year, 1 and half year, and 2 years of age.
Exclusion criteria
Exclusion criteria: 1. Less than 36 weeks of gestational age or less than 2000g of birth weight. 2. Having serious congenital anomalies. 3. Being triple and more: twins may participate in. 4. Abnormal delivery such as asphyxia (Apgar score 6 and less)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| atopic sensitization | — |
Secondary
| Measure | Time frame |
|---|---|
| immediate type of food allergy including anaphylaxis worsening of atopic dermatitis desensitization of food allergy atopic sensitization alone asthmatic bronchitis allergic rhinitis | — |
Countries
Japan
Contacts
Public ContactEiko Higuchi
Jikei University School of Medicine Molecular Epidemiology
Outcome results
None listed