Study of urinary biomarker for acute renal failure . And low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after thoracic aortic surgery: a randomised controlled trial

Study of urinary biomarker for acute renal failure . And low dose atrial natriuretic peptide provides effective renal protection from acute kidney injury after thoracic aortic surgery: a randomised controlled trial - Kawasaki biomarkers trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011558

Enrollment

Registered

2013-08-22

Start date

2013-08-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thoracic aortic aneurysm acute kidney injury

Interventions

administration of ANP(0.0125microgram kg-1 min-1) the infusion is started after induction of anesthesia and continued for 24 hours after surgery administration of 5% glucose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)thoracic aortic surgery 2)left heart bypass and cardiopulmonary bypass 3)preoperative serum creatinine1.5mg/dL or less 4)left femoral artery or escending aorta and left pulmonary vein

Exclusion criteria

Exclusion criteria: 1)case of deep hypothermic circulatory arrest 2)the arterial or venous cannulation sites were modified

Design outcomes

Primary

Measure	Time frame
the primary outcomes is the incidence of AKI within 48 hours after surgery.(serum creatinine,L-FABP,NGAL)	—

Countries

Japan

Contacts

Public ContactTakaaki Kamada

Kawasaki Saiwai Hospital Department of anesthesia

tkamada0117@nifty.com044-544-4611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026