Patients with resolved HBV infection who receive hematopoietic stem cell transplantation
Conditions
Interventions
HB vaccination
Sponsors
Kiminori Kimura
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who will undergo first HSCT 2. Patients with HBs antigen negative and HBc antibody positive 3. Patients with serum total bilirubin <=2.0mg/dl 4. Patients with serum AST and ALT <= 2.5 x ULN 5. Patients with serum creatinine <= 1.5 xULN 6. Patients with PaO2 >=60Torr on room air or SpO2 >=90% 7.Patients with performance status 0,1 or 2 8. Patients who are 20 to 75 years old 9. Patients who gave consent for this trial
Exclusion criteria
Exclusion criteria: 1. Patients with HCV antibody positive 2. Patients with HIV antibody positive 3. Patients who are allergic to vaccination 4. Patients who are allergic to biologics 5. Patients with severe infectious disease (Patients whose general condition seemed to be poor like as septic shock ) 6. Patient who undergo hemodialysis 7. Patients with mental disorder which is object of treatment 8. Patients with poorly controlled DM, HT, or heart failure 9. Patients who are pregnant or nursing 10. Patients who are judged ineligible for this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of HBV reactivation in HSCT recipients immunized with HB vaccination. | — |
Countries
Japan
Contacts
Public ContactKiminori Kimura
Tokyo Metropolitan Komagome Hospital Division of Hepatology
Outcome results
None listed