Development of human cellular models for motor neuron diseases using disease-specific induced pluripotent stem (iPS) cells

Development of human cellular models for motor neuron diseases using disease-specific induced pluripotent stem (iPS) cells - Development of cellular models for motor neuron diseases from iPS cells

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000011542

Enrollment

Registered

2013-09-01

Start date

2010-11-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult-onset motor neuron diseases (MND) including sporadic or familial amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) type IV

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Clinically diagnosed as sporadic/familial (hereditary) ALS or spinal muscular atrophy type IV, based on the guide to diagnosis and medical care by the Ministry of Health, Labour and Welfare, Japan - Confirmed gene mutations in case of familial (hereditary) ALS - Obtained informed consent in writing

Exclusion criteria

Exclusion criteria: - Presence of dementia - Difficulty in sampling

Design outcomes

Primary

Measure	Time frame
Biological property of cultured neural cells differentiated from ALS/MND-specific iPS cells, such as cellular morphology, neurite elongation, synaptogenesis, and action potentials	—

Countries

Japan

Contacts

Public ContactHitoshi Warita, MD, PhD

Tohoku University Graduate School of Medicine Neurology

warita-ns@umin.net+81-22-717-7000

Outcome results