Dry eye related to chronic GVHD
Conditions
Interventions
Tacrolimus ophthalmic solution, vitamin A ophthalmic solution, or/and sodium hyaluronate ophthalmic solution
Artifical tears, vitamin A ophthalmic solution, or/and sodium hyaluronate ophthalmic solu
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1, Newly-diagnosed dry eye patients after hematopoietic stem cell transplantation 2, Dry eye patients according to the criteria of dry eye (2006 Japanese Dry Eye society)
Exclusion criteria
Exclusion criteria: 1, Patients with Sjogren's syndrome, ocular pemphigoid, and Stevens-Johnson syndrome 2, Patients with a history of ophthalmic surgery 3, Patients wearing contact lens 4, Patients who will be applied radiation treatment during the study 5, Patients dosed cevimeline hydrochloride hydrate and /or pilocarpine(eye drop or oral drug) 6, Patients having a concern of becoming severe dry eye because of having GVHD in other organs and so on
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anterior ocular segment remark Corneal sensitivity Schirmer's test Tear film breakup time Fluorescein staining Rose-bengal staining Subjective symptom | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytotechnology(IC, BC) Biopsy Non-contact infrared meibography Laser confocal microscopy | — |
Countries
Japan
Contacts
Public ContactYoko Ogawa
Keio University School of Medicine Department of Ophthalmology
Outcome results
None listed